LQM is a specialist environmental consultancy based in Nottingham (UK) with an international reputation for assessing and managing the risks posed to human health and the environment by contaminants in soil. Increasingly this is being done within a context of sustainable development and specifically sustainable brownfield regeneration.

We provide consultancy, peer review and expert witness services, contract research and training courses on all aspects of the management of land contamination to problem holders, developers and local government.

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What are the LQM/CIEH Dose Response Roadmaps?

The Roadmaps employ a pioneering approach involving the meta-analysis of toxicological and epidemiological studies in humans and animals to produce a visual indication of the dose-response relationship over a wide range of doses (mg/kg body weight/day).

The Roadmap display the severity of the health impacts reported at given doses using a USEPA scale ranging from 0 (no effect) to 10 (death) and/or other suitable metric, such as %age cancer incidence. Symbology allows discrimination between acute, intermediate and chronic studies and between studies in animals and humans.

An example UI roadmap showing the dose response cloud (surrounded by the red dotted line) at higher doses that the current health criteria value (green dotted line)

Each Roadmap is based on outputs from a LQM and CIEH workshop held in July 2010 to analyse the toxicological reviews underpinning the Environment Agency's 2009 SGVs and/or the 2nd Edition LQM/CIEH GACs. The workshop outputs were subsequently built upon and peer reviewed leading to the development of Dose-Response Roadmaps for 18 of the most commonly encountered and difficult contaminants including arsenic, naphthalene and benzo(a)pyrene.

The Roadmaps can be purchased here

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